iv class=”bodyContent col-lg-9 mb-3″>
The Buffalo Bills have been one of the best teams through two weeks and are ascending the Super Bowl odds leaderboard as they prepare to host the Jacksonville Jaguars for Monday Night Football.
However, we expect a different story tonight from Buffalo and breakdown why the Jaguars are undervalued as a 5.5-point underdog based on the Monday Night Football odds.
Also, considering teams that get off to an 0-3 start have only made the playoffs 2% of the time in the Super Bowl era, the Jags will enter the contest with heightened desperation.
As Trevor Lawrence has struggled out of the gates, we're focusing on the Jags' run game for our prop bet.
Our Jaguars vs. Bills prediction is one part of our MNF coverage, which includes our Jaguars vs. Bills MNF props, Jaguars vs. Bills MNF parlay, and Lawrence MNF player props.
Best Jaguars vs. Bills picks
NFL picks based on the odds from our best NFL betting sites. Odds subject to change.
- Spread pick: Jaguars +5.5 (-110 via BetMGM) vs. Bills ???
- Player prop: Travis Etienne anytime touchdown scorer (+110 via FanDuel) ???
Jaguars vs. Bills spread prediction: Monday Night Football
The Bills are 2-0 and Josh Allen has the NFL's third-highest QBR (84), so many have been quick to forget how inexperienced Buffalo's receiving corps was entering the season after getting rid of Stefon Diggs.
Buffalo's passing game has been very much a committee approach, as Allen has completed passes to 10 different receivers (tied for the second-most in the league).
However, he is averaging fewer than five air yards per completion (would be a career low) as the short passing game has taken over. That is none the more evidenced by Khalil Shakir averaging 6.6 air yards per target and being targeted on 19% of his routes.
Thus, the short passing game has been effective because of Buffalo's elite running game, but I am not sure how sustainable that is going forward.
Another reason for Buffalo's success is Allen has taken much better care of the football. He did lose a fumble in Week 1 but has made it through the first two weeks without an interception for the first time since 2020.
However, Allen has never started a season without an interception through the first three games, so the player who leads the league in turnovers over the last two seasons should start to see some regression in that category.
Brenden Schaeffer also thinks the opposing quarterback will regress in his Jaguars vs. Bills MNF parlay.
The Bills' defensive depth took a hit this week when starting linebacker Terrell Bernard and slot cornerback Taron Johnson were ruled out with injuries.
In last year's 25-20 loss in London to the Jaguars, Bernard led the team with 16 tackles (eight solo) and Johnson pitched in three tackles and a quarterback hit. However, I still anticipate struggles for Jacksonville's passing game as part of my Trevor Lawrence MNF player prop bets.
Meanwhile, I expect the Jaguars to ramp up the pressure on Allen this week. The Jaguars had two players last year with double-digit sacks, and Josh Hines-Allen and Travon Walker's 27.5 combined sacks were the most by a pair of teammates in 2023.
This is a three-star play, as winless teams are 193-135-5 ATS as road underdogs, good for a 59% cover rate.
BetMGM is the only one of our best sports betting sites offering a line of +5.5, and the spread is as low as +4.5 at FanDuel. Thus, I am taking advantage of the best number at BetMGM at the standard -110 juice, as a winning $10 wager would pay out $19.09.
Best odds: -110 via BetMGM | Implied probability: 52.38%
Up To $1,500 Back In Bonus Bets
Bonus bets will expire in 7 days. One new customer offer only. Additional terms and conditions apply.
Claim $1,500
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly
Jaguars vs. Bills player prop
Our NEW NFL player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
The Bills have allowed the second-most fantasy points per game to running backs this season.
James Conner made the most of his 83 scrimmage yards by finding the endzone against Buffalo in Week 1, while Dolphins running back De'Von Achane was Miami's only source of offense against the Bills last week, totaling 165 scrimmage yards and scoring the team's only touchdown.
Etienne needs two rushing touchdowns to join Maurice Jones-Drew (54) and Fred Taylor (32) as only players in Jaguars history with 20-plus rushing touchdowns before age 26.
Considering Buffalo's defense ranks in the top seven in passer rating and yards per attempt allowed, that should force the Jaguars to lean on the running game more, while Etienne is a capable enough receiver (seven targets are tied for third-most on the team) to find the endzone via the passing game if necessary.
A winning $10 wager would net $11 in profits.
Rodrigo Villagomez is eyeing the other backfield in his first touchdown scorer predictions for Monday Night Football.
Best odds: +110 via FanDuel | Implied probability: 47.62%
Bet $5, Get $200 in Bonus Bets
New customers only. Deposit min. $10. Place first bet of $5+ and get $200 in Bonus Bets (within 72 hours).
Claim $200
Each product featured on our website has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission. 21+. Gambling can be addictive, please play responsibly
Jaguars vs. Bills odds
See all of this week's NFL odds and NFL scores.
Monday Night Football game info
- Matchup: Jaguars vs. Bills
- Kickoff: 7:30 p.m. ET
- Where: Highmark Stadium, Orchard Park, N.Y.
- How to watch: ESPN
- Weather: 68 degrees, 80% chance of precipitation, wind 12 mph SE
- Favorite: Bills (-250 via BetMGM)
NFL betting odds pages
| Super Bowl Odds | NFL MVP Odds | NFL Offensive Player of the Year Odds |
| NFL Defensive Player of the Year Odds | NFL Offensive Rookie of the Year Odds | NFL Defensive Rookie of the Year Odds |
| NFL Coach of the Year Odds | NFL Comeback Player of the Year Odds | NFL Win Totals Odds |
| NFL Playoff Odds | NFL Draft Odds |
Here are our best NFL betting sites:
- Caesars Promo Code: SBRBONUS1000 | Read our Caesars Review
- BetMGM Bonus Code: SBRBONUS | Read our BetMGM Review
- bet365 Bonus Code: SBRBONUS | Read our bet365 Review
- FanDuel Promo Code | Read our FanDuel Review
- DraftKings Promo Code | Read our DraftKings Review
(21+. Gambling Problem? Call 1-800-GAMBLER)
* Bonuses not applicable in Ontario.
Not intended for use in MA.
Each betting site featured on SBR has been meticulously researched and selected by our team of experts. If you sign up through our links, we may get a commission.
Related pages
- Best Sports Betting Sites | Best Sportsbook Promos (U.S. only)