The'Indianapolis Colts and Houston Texans open their seasons Sunday at NRG Stadium. Kickoff is set for 1:00 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the Colts vs. Texans odds, and make our expert NFL picks and predictions.
The Colts finished the 2021 season with a 26-11 loss at the Jacksonville Jaguars in Week 18 as 14-point favorites that resulted in them missing the playoffs. Indianapolis then brought in QB Matt Ryan from the Atlanta Falcons to replace QB Carson Wentz under center.
Indianapolis is the favorite to win the AFC South at -135. Colts star RB Jonathan Taylor is the favorite to finish the regular season with the most rushing yards at +425 and co-favorite with Los Angeles Rams WR Cooper Kupp to win Offensive Player of the Year at +900.
Houston is clearly in a rebuild after only winning 4 games last season. However, the Texans covered the spread in 3 of their final 4 games, including a 41-29 win as 13.5-point underdogs vs. the Los Angeles Chargers in December.