The New York Giants (1-4) visit Highmark Stadium to take on the Buffalo Bills (3-2) on Oct. 15. Kickoff is scheduled for 8:20pm EDT in Orchard Park.
The Bills are betting favorites in this Week 6 matchup, with the spread sitting at -14 (-110).
The Giants vs. Bills Over/Under is 44.5 total points for the game.
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Giants vs. Bills Prediction
Based on recent trends, the winning team model predicts the Bills will win this Week 6 game with 87.0% confidence.
Based on recent against-the-spread trends, the model predicts the Bills will cover the spread with 57.0% confidence.
Both predictions factor in up-to-date player injuries for both the Giants and Bills, plus offensive & defensive matchups, recent games and key player performances this season.
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Best Giants Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Giants players this Week 6 game, looking at profitable historical betting trends:
- Daniel Bellinger has hit the Longest Reception Under in 9 of his last 10 games (+7.80 Units / 62% ROI)
- Daniel Jones has hit the Interceptions Under in 12 of his last 15 games (+6.40 Units / 25% ROI)
- Daniel Bellinger has hit the Receptions Under in his last 6 away games (+6.00 Units / 72% ROI)
- Isaiah Hodgins has hit the Receiving Yards Over in 7 of his last 8 games (+6.00 Units / 67% ROI)
- Darius Slayton has hit the Longest Reception Over in 8 of his last 10 games (+5.60 Units / 47% ROI)
Best Bills Player Prop Best Bets Today
And here are some top NFL player prop bets for Bills players for this matchup, looking at profitable historical betting trends:
- James Cook has hit the Receiving Yards Under in his last 7 games (+7.00 Units / 74% ROI)
- Josh Allen has hit the Passing Yards Under in 10 of his last 13 games (+6.20 Units / 36% ROI)
- Josh Allen has hit the Longest Rush Under in his last 5 games (+5.00 Units / 79% ROI)
- Josh Allen has hit the Rushing Yards Under in his last 5 games (+5.00 Units / 79% ROI)
- Gabriel Davis has hit the Longest Reception Over in 7 of his last 9 games at home (+4.85 Units / 49% ROI)
Giants Best Bets:
- The New York Giants have hit the Team Total Over in 14 of their last 22 games (+4.65 Units / 18% ROI)
- The New York Giants have scored last in 7 of their last 11 away games (+4.60 Units / 39% ROI)
- The New York Giants have hit the 2Q Game Total Over in 11 of their last 19 games (+3.15 Units / 15% ROI)
- The New York Giants have hit the 4Q Moneyline in 5 of their last 11 away games (+2.50 Units / 22% ROI)
- The New York Giants have hit the 1H Game Total Over in 12 of their last 22 games (+2.30 Units / 10% ROI)
Bills Best Bets:
- The Buffalo Bills have hit the 1Q Game Total Over in 15 of their last 21 games (+8.50 Units / 35% ROI)
- The Buffalo Bills have hit the 2Q Moneyline in 13 of their last 18 games (+7.80 Units / 22% ROI)
- The Buffalo Bills have hit the 1H Moneyline in 15 of their last 21 games (+7.35 Units / 14% ROI)
- The Buffalo Bills have covered the 2Q Spread in 9 of their last 11 games at home (+6.55 Units / 51% ROI)
- The Buffalo Bills have hit the 2H Game Total Over in 7 of their last 11 games at home (+2.45 Units / 20% ROI)
Giants Against the Spread (ATS) Record
Against the spread this NFL season, the Giants went 0-5 (-5.4 Units / -100% ROI).
- Giants are 1-4 when betting on the Moneyline for -3 Units / -48% ROI
- Giants are 1-4 when betting the Over for -3.4 Units / -61.82% ROI
- Giants are 4-1 when betting the Under for +2.9 Units / ROI
Bills Against the Spread (ATS) Record
Against the spread this NFL season, the Bills went 3-2 (+0.8 Units / 14.81% ROI).
- Bills are 3-2 when betting on the Moneyline for -0.8 Units / -7.21% ROI
- Bills are 2-3 when betting the Over for -1.3 Units / -23.64% ROI
- Bills are 3-2 when betting the Under for +0.8 Units / 14.55% ROI
New York Giants: Keys to the Game vs. the Buffalo Bills
The Giants are winless (0-14) vs top 10 offenses since the 2021 season — worst in NFL; League Avg: .351.
The Giants are 1-7 (.125) when the opposing team commits less than 30 yards in penalties since the 2021 season — worst in NFL; League Avg: .475.
The Giants are winless (0-11) when having a TO margin of -2 or worse since the 2021 season — tied for worst in NFL; League Avg: .124.
The Giants are 8-17-2 (.296) when the opposing team commits less than 60 yards in penalties since the 2021 season — 3rd-worst in NFL; League Avg: .487.
Buffalo Bills: Keys to the Game vs. the New York Giants
The Bills are 5-2 (.714) vs top 10 offenses since the 2021 season — 2nd-best in NFL; League Avg: .351.
The Bills are 20-3 (.870) when converting 55% or more of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .573.
The Bills are 12-2 (.857) when rushing for 120 or more yards since the 2022 season — tied for seventh-best in NFL. The Giants have allowed an average of 146.6 rushing yards per game since the 2022 season — second-worst in NFL.
The Bills are 24-4 (.857) when allowing less than 3 sacks since the 2021 season — 2nd-best in NFL; League Avg: .592.