Giants vs Bills Odds, Pick, Prediction | NFL Sunday Night Football Preview
Sunday, Oct. 158:20 p.m. ETNBC
| Giants Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| +15-110 | 44-110o / -110u | +750 |
| Bills Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
| -15-110 | 44-110o / -110u | -1200 |
Odds via'bet365. Get up-to-the-minute'NFL odds here.
We have everything you need to know about Giants vs. Bills odds and picks for Sunday Night Football, including the spread, total an d expert prediction for the final Sunday NFL game of Week 6.
Following an unsuccessful trip to London, the Bills look to bounce back at home against the hapless Giants, who have started out 1-4 after a surprise playoff appearance in 2022.
Amazingly, this will mark New York's fourth primetime appearance over the first six weeks. If the previous three are any indication, Giants fans could be headed to bed early once again, as they've lost all three by a combined score of 94-15. The spread of over two touchdowns – largely due to the absence of Daniel Jones – would suggest a similar fate against a Buffalo team that has started 3-2 with a pair of one-possession losses and a trio of wins all by at least 28 points.
This is the NFL, which means anything can happen, but it's hard to imagine the Giants led by Tyrod Taylor have a real chance of pulling off an outright upset. Therefore, the biggest drama surrounding this dud of a matchup comes down to the spread , which has the Bills as high as 15.5-point favorites on FanDuel. The game total can be found at 43 and 43.5, depending on the book.