The San Francisco 49ers (1-1) and LA Rams (0-2) will renew their rivalry Sunday in an NFC West matchup. Kickoff from SoFi Stadium in Inglewood, Calif., is set for 4:25 p.m. ET (FOX).
Below, we look at 49ers vs. Rams odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
Both teams are coming off losses in Week 2. The 49ers were upset by the Minnesota Vikings as 4.5-point favorites, losing 23-17 on the road in Minneapolis. They now sit at 1-1 and will look to avoid a dreaded 1-2 start as the defending NFC champions. RB Christian McCaffrey (calf/Achilles) remains out after being placed on injured reserve.
The Rams are 0-2 for the first time since 2011 after losing back-to-back games to the Detroit Lions and Arizona Cardinals. They were blown out by the Cardinals Sunday, 41-10, the 2nd-worst loss of Sean McVay’s head-coaching career. WR Puka Nacua (knee) is on injured reserve, and in Sunday’s loss, WR Cooper Kupp exited early with an ankle injury.