The Kansas City Chiefs open the 2022 NFL season on the road against the Arizona Cardinals in a Week 1 late afternoon matchup. Kickoff on Sunday, Sept. 11, is 4:25 p.m. ET (FOX) at State Farm Stadium. Below, we analyze Tipico Sportsbook’s lines around the Chiefs vs. Cardinals odds and lines; check back for our NFL picks and predictions.
The Chiefs have won the AFC West 6 straight seasons and have been to the postseason 7 straight years. They will begin their quest to continue that run with QB Patrick Mahomes still leading the way, although this will be the first season without WR Tyreek Hill, who was traded to Miami' in the offseason. Mahomes will face his former Texas Tech coach, Kliff Kingsbury, who now leads the Cardinals.
The Cardinals started last season 7-0 and 10-2, but then lost 4 of their final 5 games in the regular season and were embarrassed in the first round of the playoffs. QB Kyler Murray'got a huge contract extension and now they hope to return to postseason play, only without the late-season collapse.
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