The Los Angeles Rams have the opportunity to open the 2022 NFL season at home in the first game of the year as the defending Super Bowl champions. They’ll host the Buffalo Bills, the Super Bowl favorites, on Thursday, Sept. 8 at SoFi Stadium for the season opener. Kickoff will be at 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook’s lines around the Bills vs. Rams odds and lines; check back for our NFL picks and predictions.
The Bills have the best Super Bowl odds in the NFL entering Week 1, coming in at +550. That’s slightly ahead of the Tampa Bay Buccaneers (+700) and considerably better than the team with the third-best odds, the Green Bay Packers (+1000).
Buffalo won 11 games last season and made it to the divisional round of the playoffs before losing to the Kansas City Chiefs in overtime after blowing a late lead. The Bills return QB Josh Allen and WR Stefon Diggs'and added OLB Von Miller in free agency this offseason.
Also see:'All Week 1 odds and lines