The Arizona Cardinals (1-3) are on the road in Week 5 to take on the San Francisco 49ers (2-2) on Sunday. Kickoff from Levi’s Stadium is at 4:05 p.m. ET (FOX). Below, we look at Cardinals vs. 49ers odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Cardinals have lost 2 straight games after a 41-10 win over the LA Rams in Week 2. They lost 42-14 on Sunday at home to the Washington Commanders, allowing 449 total yards and 216 on the ground. The Cardinals were 3.5-point favorites and the Over (49) hit in the loss.
The 49ers evened their record on Sunday, beating the New England Patriots 30-13, covering the 10.5-point spread as home favorites. The Over (42.5) cashed in.
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