First look: Arizona Cardinals at Buffalo Bills odds and lines
First look: Arizona Cardinals at Buffalo Bills odds and lines

The Arizona Cardinals and Buffalo Bills open their seasons Sunday. Kickoff from Highmark Stadium is scheduled for 1 p.m. ET (CBS). Below, we look at Cardinals vs. Bills odds from BetMGM Sportsbook before making our expert NFL picks and predictions later in the week.

The Cardinals are coming off a second consecutive 4-win season, but are much more optimistic this time around, as QB Kyler Murray'is healthy and played well in the 2nd half of last season.

The Bills are coming off another season winning the AFC East and then losing in the playoffs to the Kansas City Chiefs. They went 11-6 in the regular season and lost to the Chiefs in the divisional round of the playoffs. QB'Josh Allen'had 44 combined passing and rushing touchdowns last season.

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Cardinals at Bills odds

  
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