Only one No. 16 seed has ever won a game in the Round of 64: the infamous 2018 UMBC Retrievers.'
They shocked the college basketball betting world by smashing No. 1 overall seed Virginia, 74-54, and advancing to the second round of March Madness.'
UMBC lost to No. 9 seed Kansas State in the second round, 50-43.
No other No. 16 seed in the history of the NCAA Tournament has ever won a game in the Round of 64.'