Duke vs. Notre Dame prediction, odds, spread, line, start time: Proven expert releases CFB picks, best bets for Saturday's game at Wallace Wade Stadium

The No. 11 Notre Dame Fighting Irish (4-1) travel to Durham, N.C. to take on the No. 17 Duke Blue Devils (4-0) on Saturday. Kickoff is at 7:30 p.m. ET. The Irish are looking to bounce back from a heart-breaking 17-14 last second loss to Ohio State. Duke is looking to improve to 5-0 after throttling UConn 41-7 last Saturday behind a huge performance from quarterback Riley Leonard. Notre looks to extend its winning streak in r egular season games against ACC opponents to 30. Duke and Notre Dame last played in 2020 with the Irish winning 27-13.
  
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