Detroit Lions vs. San Francisco 49ers Prediction, Odds, NFL Picks – NFC Championship Game (2024)

The San Francisco 49ers will face the Detroit Lions in the NFC Championship Game of the NFL Playoffs at Levi's Stadium on Sunday, commencing at 6:30PM ET.

Dimers.com's comprehensive betting preview for Sunday's Lions vs. 49ers matchup includes the latest betting odds, as well as our predictions and picks for the game.

Lions vs. 49ers Prediction: 49ers Picked To Win By Model

We have used advanced machine learning and statistics to simulate the result of Sunday's NFL game between the Lions and 49ers 10,000 times, in keeping with our coverage of NFL picks.

Our famous predictive analytics model currently gives the 49ers a 70% chance of defeating the Lions, and our predicted final score has the 49ers winning 28-22.

  
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By Dimers