The Washington Commanders (7-6) visit Levi’s Stadium to take on the San Francisco 49ers (10-4) on Dec. 24. Kickoff is scheduled for 4:05pm EST in Santa Clara.
The 49ers are betting favorites in Week 16, with the spread sitting at -7.5 (-110).
The Commanders vs. 49ers Over/Under is 39.5 total points for the game.
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Commanders vs. 49ers Prediction for Week 16
Based on recent trends, the winning team model predicts the 49ers will win this Week 16 game with 78.0% confidence.
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 16 with 54.0% confidence.
Both predictions factor in up-to-date player injuries for both the Commanders and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
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Best Commanders Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Commanders players for Week 16, looking at profitable historical betting trends:
- Logan Thomas has hit the Receiving Yards Under in 7 of his last 8 games (+5.75 Units / 52% ROI)
- Brian Robinson has hit the Rushing Yards Over in 7 of his last 9 games (+4.70 Units / 46% ROI)
- Curtis Samuel has hit the Receptions Under in 5 of his last 6 away games (+3.85 Units / 50% ROI)
- Taylor Heinicke has hit the Interceptions Over in 7 of his last 10 games (+3.45 Units / 25% ROI)
- Jahan Dotson has hit the Receptions Under in 5 of his last 6 games (+3.25 Units / 33% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for Week 16, looking at profitable historical betting trends:
- George Kittle has hit the Receptions Under in 13 of his last 18 games (+7.00 Units / 28% ROI)
- George Kittle has hit the Receiving Yards Under in 6 of his last 7 games at home (+4.80 Units / 54% ROI)
- Christian McCaffrey has hit the Receiving Yards Over in 8 of his last 11 games (+4.80 Units / 38% ROI)
- Christian McCaffrey has hit the Rushing Yards Over in 9 of his last 13 games (+4.50 Units / 32% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 5 of his last 6 games at home (+3.85 Units / 57% ROI)
Commanders Best Bets for Week 16:
- The Washington Commanders have hit the 2H Moneyline in 8 of their last 13 games (+7.95 Units / 49% ROI)
- The Washington Commanders have hit the Moneyline in 4 of their last 5 away games (+7.30 Units / 118% ROI)
- The Washington Commanders have hit the 2H Game Total Under in 9 of their last 12 games (+6.85 Units / 52% ROI)
- The Washington Commanders have hit the Game Total Under in 9 of their last 12 games (+6.80 Units / 52% ROI)
- The Washington Commanders have hit the 1H Moneyline in 4 of their last 5 away games (+6.00 Units / 101% ROI)
49ers Best Bets for Week 16:
- The San Francisco 49ers have covered the 2Q Spread in 13 of their last 16 games (+9.95 Units / 55% ROI)
- The San Francisco 49ers have covered the Spread in 14 of their last 19 games (+8.50 Units / 40% ROI)
- The San Francisco 49ers have hit the Moneyline in 14 of their last 19 games (+8.50 Units / 19% ROI)
- The San Francisco 49ers have hit the 2Q Moneyline in 12 of their last 15 games (+8.05 Units / 33% ROI)
- The San Francisco 49ers have hit the 2H Game Total Under in 12 of their last 17 games (+7.40 Units / 39% ROI)
Commanders Against the Spread (ATS) Record
Against the spread this NFL season, the Commanders have gone 7-6 (+0.4 Units / 2.59% ROI).
- Commanders are 7-6 when betting on the Moneyline for +3.75 Units / 20.89% ROI
- Commanders are 4-9 when betting the Over for -5.9 Units / -38.31% ROI
- Commanders are 9-4 when betting the Under for +4.6 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 9-5 (+3.5 Units / 22.73% ROI).
- 49ers are 10-4 when betting on the Moneyline for +3.25 Units / 9.75% ROI
- 49ers are 6-8 when betting the Over for -2.8 Units / -18.18% ROI
- 49ers are 8-6 when betting the Under for +1.4 Units / 9.09% ROI
Washington Commanders: Keys to the Game vs. the San Francisco 49ers
The Commanders are undefeated (5-0) when leading at the end of the first half this season — tied for best in NFL; League Avg: .709.
The Commanders are 2-10 (.167) when allowing 250 or more passing yards since the 2021 season — 2nd-worst in NFL; League Avg: .464.
The Commanders are 4-9-1 (.286) when sacking the QB 3 or more times since the 2021 season — 3rd-worst in NFL; League Avg: .628.
The Commanders are winless (0-3) when rushing less than 25 times this season — tied for worst in NFL; League Avg: .318.
San Francisco 49ers: Keys to the Game vs. the Washington Commanders
The 49ers are undefeated (13-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .546.
The 49ers are 9-3 (.750) vs top 10 pass offenses since the 2021 season — 2nd-best in NFL; League Avg: .361.