The Anthony Richardson era gets underway for the Indianapolis Colts when they host Trevor Lawrence and the Jacksonville Jaguars in an AFC South rivalry game on the Week 1 NFL schedule. Richardson, the No. 4 overall pick in the 2023 NFL Draft, will be making his regular season debut for a young, rebuilding Colts team. Lawrence is set to embark on his third professional season and will be leading a talented Jaguars team that has championship aspirations in 2023. Ki ckoff from Lucas Oil Stadium in Indianapolis is scheduled for 1 p.m. ET. Jacksonville is a 5-point favorite and the over/under for total points scored is 45 points in the latest Jaguars vs. Colts odds.
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