Both the Indianapolis Colts and Denver Broncos need a statement victory heading into this Thursday night showdown. Read on for our Colts-Broncos picks.
A 0-2-1 start against AFC South teams is the Indianapolis Colts' worst divisional start since 2011. Meanwhile, Denver is coming off its seventh consecutive loss while visiting the Raiders, and the team is 0-2 against AFC West rivals for the first time in 11 seasons.
These clubs have split their last six meetings, with Indianapolis winning the previous clash 15-1 3 in 2019.
Here are our Colts-Broncos NFL picks for Week 5 (odds via FanDuel Sportsbook and Caesars Sportsbook; Pick confidence is based on a 1-to-5-star scale).