Our Sportsbook Review analysts put together a list of their expert college football picks for the Week 6 card. The picks are based on the top NCAAF odds from our best sports betting apps, and this page will serve as your one-stop shop featuring our best picks for Saturday.
We have already reached the midway point of the college football regular season, and Week 6 will tell us a lot about where this season is headed. A rivalry matchup between Texas and Oklahoma could determine who has the inside track to the Big 12 championship, while Alabama has an important litmus test against Texas A&M.
Our college football experts have put together a list of their favorite picks on many of the top games this weekend. For even more bets, check out college football Week 6 player props, college football Week 6 predictions, and college football Week 6 upset picks.
Here are our best college football bets for Week 6 (odds via our best college football betting sites; pick confidence based on a 1-to-5-star scale).
College football Top 25 schedule
(Odds via FanDuel)
- No. 23 LSU (-4.5) at No. 22 Missouri
- Maryland at No. 4 Ohio State (-19.5)
- No. 12 Oklahoma at No. 3 Texas (-6.5)
- No. 13 Washington State at UCLA (-3.5)
- No. 11 Alabama (-1.5) at Texas A&M
- Syracuse at No. 14 North Carolina (-9.5)
- Virginia Tech at No. 5 Florida State (-23.5)
- No. 20 Kentucky at No. 1 Georgia (-14.5)
- No. 2 Michigan (-19.5) at Minnesota
- No. 10 Notre Dame (-6.5) at No. 25 Louisville
- Arizona at No. 9 USC (-21.5)
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College football Week 6 expert picks
| Shane Jackson | Brenden Schaeffer | Mike Spector | Phil Wood | |
| Washington State vs. UCLA | Cameron Ward Under 2.5 touchdown passes (-115 via bet356) ??? | Logan Loya Over 39.5 receiving yards (-114 via FanDuel) ???? | Cameron Ward Under 302.5 passing yards (+102 via Caesars) ??? | UCLA -3 (-115 via bet365) ???? |
| Virginia Tech vs. Florida State | Virginia Tech +24 (-110 via Caesars) ??? | Jordan Travis Under 260.5 passing yards (-114 via FanDuel) ??? | Keon Coleman first half anytime touchdown scorer (+115 via bet365) ??? | Bhayshul Tuten Under 59.5 rushing yards (-115 via bet365) ???? |
| Syracuse vs. North Carolina | Garrett Schrader Over 33.5 rushing yards (-114 via FanDuel) ???? | Over 59.5 (-105 via FanDuel) ???? | Drake Maye Over 27.5 rushing yards (-11 0 via DraftKings) ???? | Drake Maye Over 273.5 passing yards (-114 via FanDuel) ??? |
| Wake Forest vs. Clemson | Will Shipley Under 97.5 rushing yards (-115 via DraftKings) ???? | Wake Forest team total Under 16.5 (-125 via bet365) ????? | Mitch Griffis Under 225.5 passing yards (-114 via FanDuel) ???? | Under 52.5 (-105 via Caesars) ??? |
| Vanderbilt vs. Florida | Graham Mertz Over 17.5 completions (-134 via Barstool) ????? | Florida -18.5 (-105 via FanDuel) ??? | Florida team total Over 34.5 (-125 via DraftKings) ???? | Graham Mertz Over 207.5 passing yards (-115 via DraftKings) ???? |
| UCF vs. Kansas | Daniel Hishaw Jr. Over 0.5 rushing touchdowns (+145 via DraftKings) ????? | Jason Bean Under 234.5 passing yards (-114 via FanDuel) ??? | Under 64.5 (-105 via BetMGM) ??? | Devin Neal Over 87.5 rushing yards (-115 via DraftKings) ??? |
| Arkansas vs. Ole Miss | Jaxson Dart anytime touchdown scorer (-110 via Barstool) ???? | Over 62.5 (-108 via DraftKings) ???? | K.J. Jefferson Over 1.5 passing touchdowns (+105 via DraftKings) ???? | Jaxson Dart two-plus touchdowns (+390 via DraftKings) ??? |
| Georgia Tech vs. Miami | Georgia Tech +21 (-110 via Caesars) ???? | Henry Parrish Jr. Over 71.5 rushing yards (-115 DraftKings) ???? | Miami D/ST anytime touchdown scorer (+320 via DraftKings) ??? | Haynes King Over 252.5 passing yards (-115 via DraftKings) ???? |
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College football Week 6 top picks
Hishaw has -110 (or worse) anytime touchdown odds across the board at our best sports betting apps, which is why we are taking advantage of the +145 value by shopping at DraftKings. Hishaw has to score a rushing touchdown to cash this ticket, but that shouldn't be a problem for the backup Kansas running back.
Devin Neal, who is the starting tailback for KU, is more of the pass-catching threat out of the backfield. Hishaw hasn't recorded a single catch this season, but he has scored three times in four games as the red-zone and short-yardage back. Dating back to last year, Hishaw has 10 touchdowns in nine games for the Jayhawks. He also scored one of the two touchd owns against Texas last weekend.
With starting quarterback Jalon Daniels sidelined for the second week in a row, we expect Kansas to lean on the ground game against UCF. That's great news for Hishaw and Co. in a game that has a total above 60.