College Football Week 4 opening lines, odds and best bet: Tough spot for Washington State
College Football Week 4 opening lines, odds and best bet: Tough spot for Washington State

College football Week 3 was one of the weaker slates of the season thus far, but we still had plenty of upsets and come-from-behind thrillers across the college football landscape. A few statements were made too. Texas kept rolling without Quinn Ewers, Oregon rolled against Oregon State and Indiana thrashed UCLA in its Big Ten opener.

With Week 3 in the rearview mirror, it’s time to turn our attention to Week 4. Outside of the top games, this slate isn’t as deep as some of the weeks to follow, but there is still plenty of compelling action for college football fans to enjoy. These lines opened on Sunday and have already seen plenty of movement, so let’s take a look at the college football Week 4 odds and lines, and give our first impressions. You can also find our'college football picks for all of the week’s biggest matchups.

NCAAF Week 4 opening lines and odds

  • South Alabama +7.5 (-110) vs Appalachian State – Thursday, September 19
  • Illinois +8.5 (-110) vs Nebraska – Friday, September 20
  • San Jose State +14.5 (-110) vs Washington State – Friday, September 20
  • FAU +12.5 (-110) vs Michigan State – Saturday, September 21
  • Tennessee -7.5 (-110) vs Oklahoma – Saturday, September 21
  • NC State +17 (-110) vs Clemson – Saturday, September 21
  • Utah +3 (-115) vs Oklahoma State – Saturday, September 21
  • UCLA +22.5 (-110) vs LSU – Saturday, September 21
  • Iowa -2.5 (-110) vs Minnesota – Saturday, September 21
  • Kansas +2.5 (-110) vs West Virginia – Saturday, September 21
  • Florida -4.5 (-110) vs Mississippi State – Saturday, September 21
  • USC -5.5 (-110) vs Michigan – Saturday, September 21
  • Rutgers +4.5 (-110) vs Virginia Tech – Saturday, September 21
  • Georgia Tech +10.5 (-110) vs Louisville – Saturday, September 21
  • Arkansas +4 (-110) vs Auburn – Saturday, September 21
  • TCU -2.5 (-110) vs SMU – Saturday, September 21x
  • Miami FL -17.5 (-110) vs South Florida – Saturday, September 21
  • California +2.5 (-110) vs Florida State – Saturday, September 21
  • Baylor +1.5 (-110) vs Colorado – Saturday, September 21
  • Purdue +6 (-110) vs Oregon State – Saturday, September 21
  • Kansas State -7.5 (-110) vs BYU – Saturday, September 21

We’ll have'NCAAF predictions for all the big games this week!

Best early bet for college football Week 4

  
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