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The first two weeks of the season have had a major impact on the college football championship odds.
Several AP Top 25 teams have already lost, and as we dive into our college football Week 3 odds and predictions, there could be even more upsets with this slate.
It may be a quieter schedule in Week 3, but all eyes will be on a Friday night showdown between Arizona and Kansas State, as the two Big 12 teams try to climb the college football playoff odds.
And Saturday has a few hidden gems, too, with multiple rivalry games. That includes Colorado vs. Colorado State as Shedeur Sanders and Travis Hunter look to boost their Heisman Trophy odds.
But of all the matchups, ESPN College GameDay is headed to Columbia, S.C. with LSU a 7-point favorite at our college football betting sites against South Carolina.
Co llege football picks & predictions Week 3
- Arizona State vs. Texas State early picks
- Arizona State vs. Texas State prediction (coming soon)
- Arizona State vs. Texas State player props (coming soon)
- UNLV vs. Kansas prediction (coming soon)
- UNLV vs. Kansas player props (coming soon)
- Arizona vs. Kansas State early picks
- Arizona vs. Kansas State prediction (coming soon)
- Arizona vs. Kansas State player props (coming soon)
- Tetairoa McMillan player props (coming soon)
- Alabama vs. Wisconsin early picks
- Alabama vs. Wisconsin prediciton (coming soon)
- LSU vs. South Carolina prediction (coming soon)
- Notre Dame vs. Purdue prediction (coming soon)
- UTSA vs. Texas early picks
- UTSA vs. Texas prediction (coming soon)
- Georgia vs. Kentucky prediction (coming soon)
- Colorado vs. Colorado State prediction (coming soon)
- Colorado vs. Colorado State player props (coming soon)
- Shedeur Sanders & Travis Hunter player props (coming soon)
- San Diego State vs. California prediction (coming soon)
Don't miss the rest of our Week 3 college football picks.
College football odds for Thursday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
- When: Thursday, Sept. 12 (7:30 p.m. ET)
- Where: Bobcat Stadium, San Marcos, Texas
- How to watch: ESPN
- Moneyline: Arizona State (-125) | Texas State (+105)
- Spread: Arizona State -1.5 (-112) | Texas State +1.5 (-108)
- Total: 59 (-110/-110)
College football odds for Friday
- When: Friday, Sept. 13 (7 p.m. ET)
- Where: Chil dren's Mercy Park, Kansas City
- How to watch: ESPN
- Moneyline: UNLV (+205) | Kansas (-250)
- Spread: UNLV +7 (-112) | Kansas -7 (-108)
- Total: 58 (-108/-112)
- When: Friday, Sept. 13 (8 p.m. ET)
- Where: Bill Snyder Family Stadium, Manhattan, Kans.
- How to watch: FOX
- Moneyline: Arizona (+230) | Kansas State (-285)
- Spread: Arizona +7.5 (-115) | Kansas State -7.5 (-105)
- Total: 58.5 (-108/-112)
College football odds for Saturday
- When: Saturday, Sept. 14 (noon ET)
- Where: Camp Randall Stadium, Madison, Wisc.
- How to watch: FOX
- Moneyline: Alabama (-750) | Wisconsin (+525)
- Spread: Alabama -16 (-108) | Wisconsin +16 (-112)
- Total: 50.5 (-112/-108)
- When: Saturday, Sept. 14 (noon ET)
- Wher e: Williams-Brice Stadium, Columbia, S.C.
- How to watch: ABC
- Moneyline: LSU (-250) | South Carolina (+205)
- Spread: LSU -7 (-105) | South Carolina +7 (-115)
- Total: 50 (-110/-110)
- When: Saturday, Sept. 14 (3:30 p.m. ET)
- Where: Ross-Ade Stadium, West Lafayette, Ind.
- How to watch: CBS
- Moneyline: Notre Dame (-425) | Purdue (+330)
- Spread: Notre Dame -10.5 (-112) | Purdue +10.5 (-108)
- Total: 46 (-108/-112)
- When: Saturday, Sept. 14 (7 p.m. ET)
- Where: DKR-Texas Memorial Stadium, Austin, Texas
- How to watch: ESPN
- Moneyline: OFF
- Spread: UTSA +35 (-108) | Texas -35 (-112)
- Total: 53.5 (-112/-108)
- When: Saturday, Sept. 14 (7:30 p.m. ET)
- Where: Kroger Field, Lexington, Ky.
- How to watch: AB C
- Moneyline: Georgia (-3600) | Kentucky (+1500)
- Spread: Georgia -24 (-110)| Kentucky +24 (-110)
- Total: 45 (-108/-112)
- When: Saturday, Sept. 14 (7:30 p.m. ET)
- Where: Canvas Stadium, Fort Collins, Colo.
- How to watch: CBS
- Moneyline: Colorado (-310) | Colorado State (+250)
- Spread: Colorado -7.5 (-110) | Colorado State +7.5 (-110)
- Total: 58.5 (-108/-112)
- When: Saturday, Sept. 14 (10:30 p.m. ET)
- Where: California Memorial Stadium, Berkeley, Calif.
- How to watch: ESPN
- Moneyline: San Diego State (+750) | California (-1200)
- Spread: San Diego State +18.5 (-108) | California -18.5 (-112)
- Total: 47.5 (-112/-108)
College football picks roundup: Week 3
- College football against the spread picks Week 3 (coming soon)
- College football upset picks Week 3 (coming soon)
- Big Ten predictions (coming soon)
- SEC predictions (coming soon)
- Big 12 predictions (coming soon)
- College football best bets Week 3 (coming soon)
- College football player props Week 3 (coming soon)
- College football expert picks Week 3 (coming soon)
College football betting odds pages
| College football championship odds | College football win totals | Big Ten championship odds | Mountain West championship odds |
| Heisman Trophy Odds | FCS Championship odds | Big 12 championship odds | MAC championship odds |
| College Football Playoff Odds | SEC championship odds | ACC championship odds | College bowl game odds |
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