College Football Upset Picks, Predictions: 3 Teams on Disaster Watch for Week 4
College Football Upset Picks, Predictions: 3 Teams on Disaster Watch for Week 4

James Madison is set to play its first conference game at the FBS level on Saturday. With a rest advantage and multi-point betting line move on their side, are the Dukes worth backing as +225 underdogs against the Sun Belt's resident giant-killer, Appalachian State? Here are our top college football upset picks for Week 4.

For the most part, chalk held firm in college football this past week. That didn't stop SBR's weekly “Disaster Watch” column from handing out yet another outright winner. We very nearly had t wo upset results go our way at that. Unfortunately, Old Dominion fell to Virginia on a game-winning field goal as time expired.

Luckily, Tulane came through for us later in the day by winning over Kansas State as a two-touchdown underdog on the road. After cashing at 5-1 odds, it's only fitting to have the Green Wave featured once again in this week's column. Only this time, Tulane is the team that is getting put on upset alert!

Here are our top college football upset picks for Week 4 (odds via FanDuel Sportsbook and Caesars Sportsbook).

College Football Upset Picks for Week 4

Week 4 College Football Upset Predictions

  
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