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In the most significant slate of the season to date, our college football Week 5 odds and predictions highlight the notable games involving AP Top 25 programs.
- In a Friday night ACC showdown, Cam Ward will look to continue building on his Heisman Trophy odds lead when Miami plays Virginia Tech
- With Texas a 38.5-point favorite at our college football betting sites, Arch Manning may get his second straight start for the Longhorns against lowly Mississippi State
- The best game of the week is a battle of college football championship odds favorites, with Georgia taking on Alabama
We're already a third of the way through the season, and the College Football Playoff odds are taking shape. And now Week 5 is among the most important weeks of the campaign for the College Football playoffs.
College football picks & predictions Week 5
Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
- Army vs. Temple early picks
- Army vs. Temple prediction (coming soon)
- Virginia Tech vs. Miami early picks
- Virginia Tech vs. Miami prediction (coming soon)
- Washington vs. Rutgers early picks
- Washington vs. Rutgers prediction (coming soon)
- Oklahoma State vs. Kansas State prediction (coming soon)
- Minnesota vs. Michigan (coming soon)
- Colorado vs. UCF early picks
- Colorado vs. UCF prediction (coming soon)
- Colorado vs. UCF player props (coming soon)
- Shedeur Sanders player props (coming soon)
- Louisville vs. Notre Dame prediction (coming soon)
- Mississippi State vs. Texas early picks (coming soon)
- Mississippi State vs. Texas prediction (coming soon)
- Arch Manning player props (com ing soon)
- Ohio State vs. Michigan State prediction (coming soon)
- Georgia vs. Alabama early picks
- Georgia vs. Alabama prediction (coming soon)
- Georgia vs. Alabama player props (coming soon)
- Jalen Milroe player props (coming soon)
- Arizona vs. Utah prediction (coming soon)
Don't miss the rest of our Week 5 college football picks.
College football odds for Thursday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
- When: Thursday, Sept. 26 (7:30 p.m. ET)
- Where: Lincoln Financial Field (Philadelphia, Pa.)
- How to watch: ESPN
- Moneyline: Army (-535) | Temple (+400)
- Spread: Army -13 (-112) | Temple +13 (-108)
- Total: 45.5 (-110/-110)
Col lege football odds for Friday
- When: Friday, Sept. 27 (7:30 p.m. ET)
- Where: Hard Rock Stadium (Miami Gardens, Fla.)
- How to watch: ESPN
- Moneyline: Virginia Tech (+700) | Miami (-1100)
- Spread: Virginia Tech +19.5 (-110) | Miami -19.5 (-110)
- Total: 55 (-112/-108)
- When: Friday, Sept. 27 (8 p.m. ET)
- Where: SHI Stadium (Piscataway, N.J.)
- How to watch: FOX
- Moneyline: Washington (+124) | Rutgers (-148)
- Spread: Washington +3 (-115) | Rutgers -3 (-105)
- Total: 44.5 (-108/-112)
College football odds for Saturday
- When: Saturday, Sept. 28 (noon ET)
- Where: Bill Snyder Family Stadium (Manhattan, Kans.)
- How to watch: ESPN
- Moneyline: Oklahoma State (+154) | Kansas State (-185)
- Spread: Oklahoma State +4.5 (-108) | Kansas State -4.5 (-112)
- Total: 55.5 (-108/-112)
- When: Saturday, Sept. 28 (noon ET)
- Where: Michigan Stadium (Ann Arbor, Mich.)
- How to watch: FOX
- Moneyline: Minnesota (+275) | Michigan (-345)
- Spread: Minnesota +9 (-110) | Michigan -9 (-110)
- Total: 36 (-112/-108)
- When: Saturday, Sept. 28 (3:30 p.m. ET)
- Where: FBC Mortgage Stadium (Orlando, Fla.)
- How to watch: FOX
- Moneyline: Colorado (+425) | UCF (-575)
- Spread: Colorado +15 (-112) | UCF -15 (-108)
- Total: 63 (-110/-110)
- When: Saturday, Sept. 28 (3:30 p.m. ET)
- Where: Notre Dame Stadium (Notre Dame, Ind.)
- How to watch: Peacock
- Moneyline: Louisville (+185) | Notre Dame (-225)
- Spread: Louisville +6 (-108) | Notre Dame -6 (-112)
- T otal: 47 (-110/-110)
- When: Saturday, Sept. 28 (4:15 p.m. ET)
- Where: DKR-Texas Memorial Stadium (Austin, Tex.)
- How to watch: SEC Network
- Moneyline: OFF
- Spread: Mississippi State +38.5 (-108) | Texas -38.5 (-112)
- Total: 62.5 (-105/-115)
- When: Saturday, Sept. 28 (7:30 p.m. ET)
- Where: Spartan Stadium (East Lansing, Mich.)
- How to watch: Peacock
- Moneyline: Ohio State (-2100) | Michigan State (+1100)
- Spread: Ohio State -24 (-108) | Michigan State +24 (-112)
- Total: 48.5 (-110/-110)
- When: Saturday, Sept. 28 (7:30 p.m. ET)
- Where: Bryant-Denny Stadium (Tuscaloosa, Ala.)
- How to watch: ABC
- Moneyline: Georgia (-130) | Alabama (+110)
- Spread: Georgia -2 (-112) | Alabama +2 (-108)
- Total: 48.5 (-112/-108)
- When: Saturday, Sept. 28 (10:15 p.m. ET)
- Where: Rice-Eccles Stadium (Salt Lake City, Utah)
- How to watch: ESPN
- Moneyline: Arizona (+330) | Utah (-425)
- Spread: Arizona +12 (-110) | Utah -12 (-110)
- Total: 50.5 (-108/-112)
College football picks roundup: Week 5
- College football against the spread picks Week 5
- College football upset picks Week 5 (coming soon)
- College football expert picks Week 5 (coming soon)
- College football predictions & best bets Week 5 (coming soon)
- College football player props Week 5 (coming soon)
- Big Ten predictions (coming soon)
- SEC predictions (coming soon)
- Big 12 predictions (coming soon)
College football betting odds pages
| College football championship odds | College football win totals | Big Ten championship odds | Mountain West championship odds |
| Heisman Trophy Odds | FCS Championship odds | Big 12 championship odds | MAC championship odds |
| College Football Playoff Odds | SEC championship odds | ACC championship odds | College bowl game odds |
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