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Unlike last week's slate, Week 4 has some heavy hitters with several conference games between AP Top 25 programs.
Our college football Week 4 odds and predictions look at the top games, including Tennessee vs. Oklahoma, as Nico Iamaleava looks to bolster his Heisman Trophy odds in his first SEC start.
While that's the biggest game on the schedule, Utah vs. Oklahoma State will have a massive impact on the College Football Playoff odds as both programs fight to climb the Big 12 standings.
And of course, USC vs. Michigan is a battle of two blue bloods with fanbases who expect their teams to be among the college football championship odds favorites.
The Wolverines are an underdog at our college football betting sites in USC's first conference game as a member of the Big Ten.
College football picks & predictions Week 4
Our NEW college football player prop odds tool can help you find the best odds on any market across legal sportsbooks in your area!
- South Alabama vs. Appalachian State early picks
- South Alabama vs. Appalachian State prediction (coming soon)
- Stanford vs. Syracuse early picks
- Stanford vs. Syracuse prediction (coming soon)
- Illinois vs. Nebraska early picks
- Illinois vs. Nebraska prediction (coming soon)
- Illinois vs. Nebraska player props (coming soon)
- San Jose State vs. Washington State prediction (coming soon)
- NC State vs. Clemson prediction (coming soon)
- Florida vs. Mississippi State prediction (coming soon)
- USC vs. Michigan early picks
- USC vs. Michigan prediction (coming soon)
- USC vs. Michigan player props (coming soon)
- UCLA vs. LSU prediction (coming so on)
- Utah vs. Oklahoma State (coming soon)
- Tennessee vs. Oklahoma early picks
- Tennessee vs. Oklahoma prediction (coming soon)
- Tennessee vs. Oklahoma player props (coming soon)
- Baylor vs. Colorado prediction (coming soon)
- Baylor vs. Colorado player props (coming soon)
- Shedeur Sanders player props (coming soon)
- Kansas State vs. BYU prediction (coming soon)
Don't miss the rest of our Week 4 college football picks.
College football odds for Thursday
College football odds via DraftKings and subject to change. Follow the latest college football scores for line history and matchup info.
- When: Thursday, Sept. 19 (7:30 p.m. ET)
- Where: Kidd Brewer Stadium (Boone, N.C.)
- How to watch: ESPN
- Moneyline: South Alabama (+235) | Appalachian State (-290)
- Sprea d: South Alabama +8 (-110) | Appalachian State -8 (-110)
- Total: 64 (-108/-112)
College football odds for Friday
- When: Friday, Sept. 20 (7:30 p.m. ET)
- Where: JMA Wireless Dome (Syracuse, N.Y.)
- How to watch: ESPN
- Moneyline: Stanford (+275) | Syracuse (-345)
- Spread: Stanford +10 (-112) | Syracuse -10 (-108)
- Total: 57.5 (-108/-112)
- When: Friday, Sept. 20 (8 p.m. ET)
- Where: Memorial Stadium (Lincoln, Neb.)
- How to watch: FOX
- Moneyline: Illinois (+285) | Nebraska (-360)
- Spread: Illinois +10 (-115) | Nebraska -10 (-105)
- Total: 43 (-110/-110)
- When: Friday, Sept. 20 (10 p.m. ET)
- Where: Gesa Field (Pullman, Wash.)
- How to watch: The CW Network
- Moneyline: San Jose State (+410) | Washington State (-550)
- Spread: San Jose State +13.5 (-108) | Washington State -13.5 (-112)
- Total: 56.5 (-110/-110)
College football odds for Saturday
- When: Saturday, Sept. 21 (noon ET)
- Where: Memorial Stadium (Clemson, S.C.)
- How to watch: ABC
- Moneyline: NC State (+700) | Clemson (-1100)
- Spread: NC State +20.5 (-112) | Clemson -20.5 (-108)
- Total: 47 (-112/-108)
- When: Saturday, Sept. 21 (noon ET)
- Where: Davis Wade Stadium (Starkville, Miss.)
- How to watch: ESPN
- Moneyline: Florida -5.5 (-205) | Mississippi State (+170)
- Spread: Florida -5.5 (-110) | Mississippi State +5.5 (-110)
- Total: 58.5 (-110/-110)
- When: Saturday, Sept. 21 (3:30 p.m. ET)
- Where: Michigan Stadium (Ann Arbor, Mich.)
- How to watch: CBS
- Moneyline: USC (-218) | Michigan (+180)
- Spread: USC -5.5 (-112) | Michigan +5.5 (-108)
- Total: 47 (-108/-112)
- When: Saturday, Sept. 21 (3:30 p.m. ET)
- Where: Tiger Stadium (Baton Rouge, La.)
- How to watch: ABC
- Moneyline: UCLA (+1100) | LSU (-2100)
- Spread: UCLA +24.5 (-110) | LSU -24.5 (-110)
- Total: 56 (-110/-110)
- When: Saturday, Sept. 21 (4 p.m. ET)
- Where: Boone Pickens Stadium (Stillwater, Okla.)
- How to watch: FOX
- Moneyline: Utah (-130) | Oklahoma State (+110)
- Spread: Utah -2.5 (-110) | Oklahoma State +2.5 (-110)
- Total: 52 (-108/-112)
- When: Saturday, Sept. 21 (7:30 p.m. ET)
- Where: Memorial Stadium (Norman, Okla.)
- How to watch: ABC
- Moneyline: Tennessee (-265) | Oklahoma (+2 15)
- Spread: Tennessee -7 (-115) | Oklahoma +7 (-105)
- Total: 57.5 (-110/-110)
- When: Saturday, Sept. 21 (8 p.m. ET)
- Where: Folsom Field (Boulder, Colo.)
- How to watch: FOX
- Moneyline: Baylor (+110) | Colorado (-130)
- Spread: Baylor +2 (-110) | Colorado -2 (-110)
- Total: 52.5 (-112/-108)
- When: Saturday, Sept. 21 (10:30 p.m. ET)
- Where: LaVell Edwards Stadium (Provo, Utah)
- How to watch: ESPN
- Moneyline: Kansas State (-250) | BYU (+205)
- Spread: Kansas State -7 (-108) | BYU +7 (-112)
- Total: 47.5 (-110/-110)
College football picks roundup: Week 4
- College football against the spread picks Week 4 (coming soon)
- College football upset picks Week 4 (coming soon)
- College football expert picks Week 4 (coming soon)
- Big Ten predictions (coming soon)
- SEC predictions (coming soon)
- Big 12 predictions (coming soon)
- College football predictions & best bets Week 4 (coming soon)
- College football player props Week 4 (coming soon)
College football betting odds pages
| College football championship odds | College football win totals | Big Ten championship odds | Mountain West championship odds |
| Heisman Trophy Odds | FCS Championship odds | Big 12 championship odds | MAC championship odds |
| College Football Playoff Odds | SEC championship odds | ACC championship odds | College bowl game odds |
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