College football odds are back with Week 0 betting on Saturday, Aug. 27. And there are a variety of different spreads – from huge home favorites to short road underdogs – there's something for everyone.
Here are the biggest NCAAF spreads this week, ranked from highest to lowest:
College Football Odds Week 0: Biggest NCAAF Spreads This Week
| Rank | Matchup | Spread |
| 1 | Connecticut at Utah State | Utah State -27.5 |
| 2 | Northwestern at Nebraska | Nebraska -12.5 |
| 3 | Wyoming at Illinois | Illinois -10 |
| 4 | Nevada at New Mexico State | Nevada -9.5 |
| 5 | Charlotte at Florida Atlantic | Florida Atlantic -7.5 |
| 6 | Vanderbilt at Hawaii | Vanderbilt -7 |
| 7 | North Texas at UTEP | North Texas -1 |
1. Connecticut at Utah State (-27.5)
The UConn Huskies are nearly four-touchdown underdogs in the first game of the Jim Mora era.
They face the reigning Mountain West champions in the Utah State Aggies, who finished 11-3 in Blake Anderson's first season at the helm.