College football odds, lines, spreads: Picks, predictions, betting advice for Week 1, 2022 from proven model
College football odds, lines, spreads: Picks, predictions, betting advice for Week 1, 2022 from proven model

After 11 games took place on Aug. 27, every team will be in action during the Week 1 college football schedule. Games will take place from Thursday through Monday, with all 25 ranked teams in action, including three matchups of ranked teams. The headline contest will be Notre Dame vs. Ohio State as both teams bring top-5 rankings into their 7:30 p.m. ET kickoff on Saturday night. The No. 2 Buckeyes are 17.5-point favorites over the No. 5 Irish in the latest Week 1 college football odds per Caesars Sportsbook. Other key m atchups include Georgia vs. Oregon on Saturday and Clemson vs. Georgia Tech on Labor Day.

Before making any college football picks for those games or others in Week 1, be sure to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 1 of FBS college football, a nd the results are in.'

  
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