The Cleveland Guardians (65-56) and the San Diego Padres (68-57) wrap up a 2-game interleague series at Petco Park. First pitch is scheduled for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook’s lines around the Guardians vs. Padres odds with MLB picks and predictions.
Season series: Guardians lead 2-1
The Guardians registered a 3-1 victory in the series opener Tuesday as the bullpen pitched 4 1/3-scoreless IP of relief to help the visitors to the win. Cleveland looks to continue its success against left-handed starting pitchers, going 6-1 in the past 7 tries against southpaws.
The Padres have really struggled scoring runs, totaling just 9 runs in the past five outings, going 2-3 during the span. Luckily the pitching staff has done a good job giving the team a chance, allowing 3 or fewer runs in 4 of the past 5 contests.