An ACC battle is on tap between the Clemson Tigers and the Syracuse Orange at 7 p.m. ET on Wednesday at Littlejohn Coliseum. Clemson is 19-8 overall and 13-1 at home, while 'Cuse is 16-11 overall and 5-4 on the road. The Tigers are favored by 5 points in the latest Clemson vs. Syracuse odds from Caesars Sportsbook and the over/under is set at 146. Before you make any Syracuse vs. Clemson picks and predictions, you'll want to see what the SportsLine Projection Model is saying.
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