Clemson vs. Notre Dame Prediction: Picks & Start Time – November 2022

The No. 5 Clemson Tigers (8-0) and Notre Dame Fighting Irish (5-3) will face each other at Notre Dame Stadium in South Bend, Indiana.

Clemson vs. Notre Dame Odds

The spread for this matchup is set at 3.5 points, with oddsmakers listing Clemson as the favorites.

As for the moneyline, Clemson has -186 odds to pick up the win, while Notre Dame is listed at +153 to claim victory.

Finally, the over/under for the game is set at 43.5 points.

  
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