Chiefs vs Colts Prediction, Odds & Best Prop Bets – NFL, Week 3
Chiefs vs Colts Prediction, Odds & Best Prop Bets – NFL, Week 3

The Kansas City Chiefs (2-0) visit Lucas Oil Stadium to take on the Indianapolis Colts (0-1) on Sep. 25. Kickoff is scheduled for 1:00pm EDT in Indianapolis.

The Chiefs are betting favorites in Week 3, with the spread sitting at -7 (-110).

The Chiefs vs. Colts Over/Under is 49.5 total points for the game.

Bet now on Colts vs Chiefs & all NFL games with BetMGM

Chiefs vs. Colts Prediction for Week 3

Based on recent trends, the winning team model predicts the Chiefs will win this Week 3 game with 69.3% confidence.

Based on recent against-the-spread trends, the model predicts the Colts will cover the spread this Week 3 with 55.0% confidence.

Both predictions factor in up-to-date player injuries for both the Chiefs and Colts, plus offensive & defensive matchups, recent games and key player performances this season.


Best Chiefs Player Prop Bets Today

We’ve highlighted some favorite NFL player prop bets for Chiefs players for Week 3, looking at profitable historical betting trends:

  • Patrick Mahomes has hit the Passing Yards Under in 14 of his last 20 games (+6.70 Units / 27% ROI)
  • Mecole Hardman has hit the Receptions Under in 11 of his last 15 games (+6.00 Units / 26% ROI)
  • Patrick Mahomes has hit the Completions Over in 6 of his last 8 away games (+4.00 Units / 45% ROI)
  • Patrick Mahomes has hit the Rushing Yards Over in 6 of his last 8 away games (+3.80 Units / 41% ROI)
  • Mecole Hardman has hit the Receiving Yards Under in 5 of his last 7 away games (+2.60 Units / 30% ROI)

Best Colts Player Prop Best Bets Today

And here are some top NFL player prop bets for Colts players for Week 3, looking at profitable historical betting trends:

  • Jonathan Taylor has hit the Receiving Yards Under in 13 of his last 17 games (+7.85 Units / 37% ROI)
  • Nyheim Hines has hit the Rushing Yards Under in 9 of his last 12 games (+5.30 Units / 35% ROI)
  • Nyheim Hines has hit the Receiving Yards Over in 5 of his last 6 games at home (+3.85 Units / 57% ROI)
  • Jonathan Taylor has hit the Rushing Yards Over in 11 of his last 17 games (+3.80 Units / 19% ROI)
  • Matt Ryan has hit the Rushing Yards Under in 6 of his last 9 games (+2.15 Units / 18% ROI)

  • The Kansas City Chiefs have hit the 1Q Moneyline in 11 of their last 15 games (+9.40 Units / 32% ROI)
  • The Kansas City Chiefs have hit the Moneyline in 13 of their last 15 games (+7.80 Units / 16% ROI)
  • The Kansas City Chiefs have scored first in 14 of their last 18 games (+7.60 Units / 25% ROI)
  • The Kansas City Chiefs have covered the 1Q Spread in 11 of their last 15 games (+7.05 Units / 44% ROI)
  • The Kansas City Chiefs have hit the 2H Moneyline in 7 of their last 8 away games (+6.60 Units / 38% ROI)

  • The Indianapolis Colts have covered the 1H Spread in 12 of their last 16 games (+7.55 Units / 42% ROI)
  • The Indianapolis Colts have hit the Game Total Under in their last 7 games (+7.00 Units / 91% ROI)
  • The Indianapolis Colts have hit the 1H Game Total Under in 6 of their last 7 games (+6.00 Units / 77% ROI)
  • The Indianapolis Colts have hit the Team Total Under in their last 5 games (+5.00 Units / 90% ROI)
  • The Indianapolis Colts have covered the 2Q Spread in 11 of their last 17 games (+4.65 Units / 25% ROI)

Chiefs Against the Spread (ATS) Record

Against the spread this NFL season, the Chiefs have gone 1-1 (-0.1 Units / -4.55% ROI).

  • Chiefs are 2-0 when betting on the Moneyline for +2 Units / 43.48% ROI
  • Chiefs are 1-1 when betting the Over for -0.1 Units / -4.55% ROI
  • Chiefs are 1-1 when betting the Under for -0.1 Units / ROI

Colts Against the Spread (ATS) Record

Against the spread this NFL season, the Colts have gone 0-2 (-2.15 Units / -100% ROI).

  • Colts are 0-1 when betting on the Moneyline for -1.6 Units / -32.65% ROI
  • Colts are 0-2 when betting the Over for -2.2 Units / -100% ROI
  • Colts are 2-0 when betting the Under for +2 Units / 90.91% ROI

Kansas City Chiefs: Keys to the Game vs. the Indianapolis Colts

The Chiefs were 1-2 (.333) when rushing less than 20 times last season — tied for 3rd-best in NFL; League Avg: .121.

The Chiefs are 2-2 (.500) when the opposing team rushes more than 30 times since the 2021 season — tied for best in NFL; League Avg: .172.

The Chiefs were 2-2 (.500) when the opposing team rushes more than 30 times last season — tied for best in NFL; League Avg: .165.

The Chiefs were undefeated (8-0) when allowing less than 22 points last season — tied for best in NFL; League Avg: .762.

Indianapolis Colts: Keys to the Game vs. the Kansas City Chiefs

The Colts were winless (0-2) when rushing less than 20 times last season — tied for worst in NFL; League Avg: .121.

The Colts are winless (0-3) when the opposing team rushes more than 30 times since the 2021 season — tied for worst in NFL; League Avg: .172.

  
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