The Chicago White Sox (24-63) and Cleveland Guardians (53-30) play the middle contest of a 3-game series Wednesday. First pitch from Progressive Field is scheduled for 6:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the White Sox vs. Guardians odds and make our expert MLB picks and predictions for the best bets.
Season series: Tied 4-4
The Guardians walked it off with a sacrifice fly from pinch-hitter Bo Naylor in the bottom of the 9th inning for a 7-6 win over the last-place White Sox in a wild seesaw battle in Tuesday’s series opener. Despite the win, Cleveland is just 4-4 this season against Chicago.
Cleveland is 13-9 inside the AL Central, while going only 2-4 in the past 6 tries inside the division. The Under has a 12-10 edge in 22 divisional matchups.