Chelsea are 10 points behind league-leaders Arsenal and occupy sixth place in the table, three points outside of the top four. Check out our Chelsea-Arsenal picks.
The Blues are winless in their last three matches, including a 4-1 defeat at head coach Graham Potter's former club, Brighton, last weekend.
Meanwhile, Mikel Arteta's Gunners are flying. They were unbeaten in the Premier League in October, which featured wins over Liverpool and Tottenham.
Here are our Chelsea-Arsenal Premier League picks for Matchday 15 (odds via DraftKings Sportsbook and FanDuel Sportsbook; pick confidence based on a 1-to-5-star scale).