Monday Night Football in Week 16 pits the playoff-hopeful Los Angeles Chargers against the Indianapolis Colts following the three-game Christmas Day slate. Read on for our top Chargers vs. Colts NFL pick.
Los Angeles (8-6) hopes for its second three-game winning streak of the season. Its current two-game streak catapulted its odds of making the playoffs to 93% (per ESPN Analytics), as its final three opponents have a combined record of 12-28-1.
Indianapolis (4-9-1) lost four consecutive ga mes, none worse than last week's defeat against the Minnesota Vikings. The Colts squandered a 33-0 third-quarter lead and became the first team in NFL history to lose a game when leading by 33+ points.
Here is our best Chargers vs. Colts NFL Week 16 pick (odds via DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).