The top two favorites in a loaded AFC West meet Thursday night as the Kansas City Chiefs host the Los Angeles Chargers. Read on for our Chargers-Chiefs picks.
Chiefs quarterback Patrick Mahomes is 5-2 in his career against the Chargers. Kansas City is also 13-3 in its last 16 meetings with Los Angeles; however, the Chargers won two of the previous three meetings and both victories came at Arrowhead Stadium. Mahomes and many other Chiefs starters rested in their Week 17 matchup in 2020.
The Chiefs have won six straight home openers, and whoever wins this matchup will own sole possession of first place as the only undefeated AFC West team after two weeks.
Here are our Chargers-Chiefs NFL picks for Week 2 (odds via FanDuel Sportsbook, PointsBet, and BetMGM; pick confidence based on a 1-to-5-star scale).