The Los Angeles Chargers (5-3) visit Levi’s Stadium to take on the San Francisco 49ers (4-4) on Nov. 13. Kickoff is scheduled for 8:20pm EST in Santa Clara.
The 49ers are betting favorites in Week 10, with the spread sitting at -7 (-110).
The Chargers vs. 49ers Over/Under is 46.5 total points for the game.
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Chargers vs. 49ers Prediction for Week 10
Based on recent trends, the winning team model predicts the 49ers will win this Week 10 game with 76.3% confidence.
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 10 with 52.0% confidence.
Both predictions factor in up-to-date player injuries for both the Chargers and 49ers, plus offensive & defensive matchups, recent games and key player performances this season.
Best Chargers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Chargers players for Week 10, looking at profitable historical betting trends:
- Gerald Everett has hit the Receptions Over in 11 of his last 15 games (+7.45 Units / 43% ROI)
- Justin Herbert has hit the Interceptions Over in 11 of his last 16 games (+6.60 Units / 39% ROI)
- Justin Herbert has hit the Completions Over in 7 of his last 8 away games (+6.05 Units / 71% ROI)
- Austin Ekeler has hit the Receiving Yards Over in 11 of his last 16 games (+5.55 Units / 31% ROI)
- Austin Ekeler has hit the Receptions Over in 10 of his last 15 games (+5.50 Units / 32% ROI)
Best 49ers Player Prop Best Bets Today
And here are some top NFL player prop bets for 49ers players for Week 10, looking at profitable historical betting trends:
- Deebo Samuel has hit the Receptions Under in 13 of his last 18 games (+6.40 Units / 25% ROI)
- Tajae Sharpe has hit the Receiving Yards Under in his last 5 games (+5.00 Units / 81% ROI)
- Jimmy Garoppolo has hit the Completions Under in 11 of his last 16 games (+4.80 Units / 23% ROI)
- George Kittle has hit the Receptions Under in 12 of his last 18 games (+4.45 Units / 17% ROI)
- Brandon Aiyuk has hit the Receiving Yards Over in 12 of his last 20 games (+3.05 Units / 14% ROI)
Chargers Team Props for Week 10:
- The Los Angeles Chargers have covered the 2Q Spread in 11 of their last 13 games (+8.65 Units / 60% ROI)
- The Los Angeles Chargers have hit the 2Q Game Total Over in 12 of their last 17 games (+7.40 Units / 37% ROI)
- The Los Angeles Chargers have hit the 3Q Game Total Under in 11 of their last 15 games (+6.30 Units / 38% ROI)
- The Los Angeles Chargers have hit the 2Q Moneyline in 8 of their last 10 games (+6.15 Units / 39% ROI)
- The Los Angeles Chargers have scored last in 7 of their last 8 away games (+5.75 Units / 55% ROI)
49ers Team Props for Week 10:
- The San Francisco 49ers have hit the Game Total Under in 12 of their last 16 games (+7.60 Units / 43% ROI)
- The San Francisco 49ers have covered the Spread in 14 of their last 20 games (+7.55 Units / 34% ROI)
- The San Francisco 49ers have hit the 1Q Moneyline in 10 of their last 20 games (+6.10 Units / 21% ROI)
- The San Francisco 49ers have covered the 2Q Spread in 8 of their last 10 games (+6.00 Units / 54% ROI)
- The San Francisco 49ers have hit the Moneyline in 6 of their last 7 games at home (+5.60 Units / 29% ROI)
Chargers Against the Spread (ATS) Record
Against the spread this NFL season, the Chargers have gone 5-3 (+1.7 Units / 19.32% ROI).
- Chargers are 5-3 when betting on the Moneyline for -0.95 Units / -6.44% ROI
- Chargers are 4-4 when betting the Over for -0.4 Units / -4.55% ROI
- Chargers are 4-4 when betting the Under for -0.4 Units / ROI
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 4-4 (-0.4 Units / -4.57% ROI).
- 49ers are 4-4 when betting on the Moneyline for -2.75 Units / -17.74% ROI
- 49ers are 3-5 when betting the Over for -2.5 Units / -28.41% ROI
- 49ers are 5-3 when betting the Under for +1.7 Units / 19.32% ROI
Los Angeles Chargers: Keys to the Game vs. the San Francisco 49ers
The Chargers are 4-1 (.800) when forcing 1 or more turnovers this season — ninth-best in NFL. The 49ers have turned the ball over 13 times this season — tied for fourth-most in NFL.
The Chargers are undefeated (3-0) when not throwing an interception this season — tied for best in NFL; League Avg: .641.
The Chargers are 2-1 (.667) on the road this season — tied for 6th-best in NFL; League Avg: .452.
The Chargers are 2-1 (.667) when allowing less than 5 yards per rush this season — tied for 8th-best in NFL; League Avg: .525.
San Francisco 49ers: Keys to the Game vs. the Los Angeles Chargers
The 49ers are 2-1 (.667) when getting more than 3 points since the 2021 season — tied for 2nd-best in NFL; League Avg: .309.
The 49ers are undefeated (9-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .541.