Champions League soccer predictions and UCL best bets for Wednesday 2/22: Tricky first leg for Manchester City

The final slate of Champions League round-of-16 first-leg games takes place on Wednesday, with teams from Portugal, Italy, England and Germany in action. Inter Milan is a strong favorite at home to Porto, but RB Leipzig is a home underdog for the visit of EPL team Manchester City.

We’ve picked out our best bets for each of those matchups on Wednesday afternoon, but make sure you check out the rest of our soccer predictions which include this weekend’s EPL matches. Both games kick off at 3:oopm ET and can be viewed on Paramount+. with Leipzig vs Manchester City also being shown on CBS. Odds shown are available at the time of publishing.

You can bet any of our soccer predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you can get a No Sweat First Bet of up to $1,000. Click here to join FanDuel right now.

Inter Milan vs Porto best bet: Under 2.5 goals (-130)

Inter against Porto is expected to be a tight matchup over the 180 minutes of the two-legged Champions League round-of-16 tie. Neither team is used to losing or allowing many goals, so we should expect a close first leg in Italy. Porto's season really got going during the Champions League group stage, as it won its final 4 games of the first round to claim 1st place in the group, and now returns to European action on a 10-game winning streak.

  
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