USC has had trouble with Stanford in the past, but will Lincoln Riley's presence change all of that? The Trojans will need to play a great game in order to overcome the Cardinal in enemy territory on Saturday September 10, 2022 at 7:30PM ET. USC did look dominant in its Week 1 win over Rice, but this is big step up in competition and Stanford turned in a good performance in its opener.
Will the Cardinal faithful help their team pull off this upset? You'll just have to keep reading our USC vs. Stanford betting preview to find out.
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For the most up to date CFB computer picks, check out our interactive predictions for USC vs. Stanford. It's constantly updating based on hundreds of different data points.