Patrick Mahomes II, who ranks fourth-best in the league in passing yards, will aim to lead the charge for the Kansas City Chiefs (4-1) on October 16 at 4:25 PM ET, when they host the Buffalo Bills (4-1) and their fourth-best pass D (182.6 passing yards allowed per game).
In their last game, the Bills defeated the Pittsburgh Steelers 38-3. The Chiefs’ last game was a 30-29 win over the Las Vegas Raiders. Josh Allen had 424 yards on 20-of-31 passing (64.5%) for the Bills in that matchup against the Steelers, with four touchdowns and one interception. He also added five carries for 42 yards. Devin Singletary rushed for 42 yards on six carries (7.0 yards per carry), adding one reception for four yards. Gabriel Davis hauled in three receptions for 171 yards (averaging 57.0 per catch), while scoring two touchdowns against the Steelers. Mahomes threw for 292 yards for the Chiefs against the Raiders, going 29-for-43 (67.4%) with four touchdowns and no interceptions. He added four carries for 28 yards. Jerick McKinnon put together an eight-carry, 53-yard game (6.6 yards per attempt), while also adding two receptions for 19 yards . Marquez Valdes-Scantling recorded 90 yards through the air after six catches (on eight targets).
See below as we dive into all of the info you need before this matchup begins, including how to watch on TV.
Bills vs. Chiefs Betting Information
National Football League odds courtesy of Tipico Sportsbook. Odds updated Tuesday at 11:28 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: Bills (-3)
- Moneyline: Bills (-147), Chiefs (+124)
- Total: 54 points