Buffalo Bills at Detroit Lions odds, picks and predictions

The Buffalo Bills (7-3) and Detroit Lions (4-6) open Thanksgiving’s triple-header with the early game from Ford Field at 12:30 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the Bills vs. Lions odds, and make our expert NFL picks and predictions.

QB Josh Allen and the Bills beat the Cleveland Browns at Ford Field 31-23 last week, covering the spread as 7.5-point favorites. The game was moved to Detroit due to a snowstorm in Western New York.'Allen threw for 197 yards with a TD in the victory.

The Lions, who were 3-point underdogs, went on the road and beat the New York Giants 31-18 in Week 11. Detroit was able to hold New York RB Saquon Barkley to 22 rushing yards on 15 carries.

If the Lions want to win this matchup, they’ll need to stop the 6-foot-5, 240-pound Allen from running and throwing all over them. It will be a challenging task for Detroit, which is 37-43-2 on Thanksgiving.

  
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