:format(webp)/cdn.vox-cdn.com/uploads/chorus_image/image/71343049/usa_today_17211673.0.jpg "Browns vs. Panthers predictions: Spread pick, over/under, best bets, player props for Week 1 NFL matchup")
The Cleveland Browns and Carolina Panthers will face off Week 1 to kickoff the 2022 NFL season. Kickoff is set for 1:00 p.m. ET from Bank of America Stadium in Charlotte, NC, while the game will be broadcast on CBS.
Here, we'll take a look at our picks for best bets for Browns vs. Panthers in Week 1 of the NFL season.
Browns vs. Panthers odds
Spread: Panthers -1.5 (-110)
Point total: O 42 (-110), U 42 (-110)
Moneyline: Panthers (-125), Browns (+105)
Our picks, best bets
Pick against the spread: Panthers -1.5
This is a revenge game for Baker Mayfield and I think he's going to have a big game. With Jacoby Brissett at quarterback, the Browns will have a hard time scoring. Brissett was 2-3 as a starter last season. The Panthers offense has a number of playmakers and a healthy Christian McCaffrey which will be the difference maker.
Over/under: U 42 (-110)
I think this score will be somewhere around 14-10 with the Panthers winning. Both teams like to run the ball which will keep the clock ticking. 58.8% of Browns games went under last season. Their defense should be good and their offense will struggle. This game has the perfect makings for the under.
Player prop: Christian McCaffrey over 46.5 receiving yards (-115)
In Week 1 last season, McCaffrey had 89 receiving yards. With Matt Rhule at head coach, the Panthers have shown they will throw the ball to McCaffrey a bunch to give him a chance to make plays with space in front of him. To build Mayfield's confidence, look for Carolina to throw some underneath passes and screens and McCaffrey to be involved in a majority of those.