There are not many better traditions in football than the Detroit Lions hosting the first game on Thanksgiving Day, and this year's version has the Buffalo Bills coming to town on Thanksgiving for the first time since 1994. Read on for our Bills-Lions picks.
The Bills (7-3) had time to get comfortable with their surroundings at Ford Field for this week, as they are coming off a 31-23 victory over Cleveland in a game that was moved from Buffalo because of weather. The win snapped a season-high two-game losing streak for Buffalo and pulled the team even with Miami atop the AFC East standings.
Detroit (4-6) is in the midst of its first three-game winning streak since 2017 and is coming off a 31-18 road win over the previously 7-2 New York Giants. The win was the Lions' first by double-digits this season.
Here are our Bills-Lions NFL picks for Week 12 (odds via PointsBet, DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).