The Buffalo Bills (7-3) visit Ford Field to take on the Detroit Lions (4-6) on Nov. 24. Kickoff is scheduled for 12:30pm EST in Detroit on Thanksgiving day.
The Bills are betting favorites in Week 12, with the spread sitting at -9.5 (-110).
The Bills vs. Lions Over/Under is 54 total points for the game.
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Bills vs. Lions Prediction for Week 12
Based on recent trends, the winning team model predicts the Bills will win this Week 12 game with 77.0% confidence.
Based on recent against-the-spread trends, the model predicts the Bills will cover the spread this Week 12 with 53.0% confidence.
Both predictions factor in up-to-date player injuries for both the Bills and Lions, plus offensive & defensive matchups, recent games and key player performances this season.
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Best Bills Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for Bills players for Week 12, looking at profitable historical betting trends:
- Josh Allen has hit the Rushing Yards Over in 14 of his last 19 games (+8.35 Units / 38% ROI)
- Josh Allen has hit the Pass Attempts Under in 10 of his last 13 games (+6.30 Units / 38% ROI)
- Josh Allen has hit the Carries Over in his last 6 away games (+6.15 Units / 85% ROI)
- Gabriel Davis has hit the Receiving Yards Over in 12 of his last 17 games (+6.15 Units / 32% ROI)
- Nyheim Hines has hit the Rushing Yards Under in 7 of his last 8 games (+5.80 Units / 58% ROI)
Best Lions Player Prop Best Bets Today
And here are some top NFL player prop bets for Lions players for Week 12, looking at profitable historical betting trends:
- Jared Goff has hit the TD Passes Over in 8 of his last 9 games at home (+8.30 Units / 86% ROI)
- Jamaal Williams has hit the Receiving Yards Under in 10 of his last 12 games (+7.45 Units / 48% ROI)
- Josh Reynolds has hit the Receiving Yards Over in 9 of his last 11 games (+7.05 Units / 57% ROI)
- Jamaal Williams has hit the Rushing Yards Over in 9 of his last 12 games (+5.80 Units / 42% ROI)
- Amon-Ra St. Brown has hit the Receptions Over in 6 of his last 7 games at home (+5.05 Units / 64% ROI)
Bills Best Bets for Week 12:
- The Buffalo Bills have scored first in 13 of their last 16 games (+8.35 Units / 29% ROI)
- The Buffalo Bills have hit the 1Q Game Total Over in 11 of their last 14 games (+7.40 Units / 45% ROI)
- The Buffalo Bills have covered the 2H Spread in 12 of their last 17 games (+6.60 Units / 35% ROI)
- The Buffalo Bills have hit the 1H Game Total Over in 11 of their last 16 games (+6.50 Units / 36% ROI)
- The Buffalo Bills have hit the 2Q Moneyline in 6 of their last 9 games (+6.00 Units / 32% ROI)
Lions Best Bets for Week 12:
- The Detroit Lions have hit the Moneyline in 5 of their last 8 games at home (+8.50 Units / 97% ROI)
- The Detroit Lions have hit the 1H Moneyline in 8 of their last 16 games (+8.40 Units / 50% ROI)
- The Detroit Lions have covered the 1H Spread in 11 of their last 16 games (+6.75 Units / 39% ROI)
- The Detroit Lions have hit the 2Q Moneyline in 6 of their last 8 games at home (+5.95 Units / 67% ROI)
- The Detroit Lions have hit the 3Q Game Total Over in 7 of their last 8 games at home (+5.90 Units / 65% ROI)
Bills Against the Spread (ATS) Record
Against the spread this NFL season, the Bills have gone 5-4 (+0.6 Units / 5.43% ROI).
- Bills are 7-3 when betting on the Moneyline for -3.2 Units / -8.79% ROI
- Bills are 3-7 when betting the Over for -4.7 Units / -42.73% ROI
- Bills are 7-3 when betting the Under for +3.7 Units / ROI
Lions Against the Spread (ATS) Record
Against the spread this NFL season, the Lions have gone 6-4 (+1.5 Units / 13.57% ROI).
- Lions are 4-6 when betting on the Moneyline for -1.15 Units / -10.65% ROI
- Lions are 7-3 when betting the Over for +3.7 Units / 33.64% ROI
- Lions are 3-7 when betting the Under for -4.7 Units / -42.73% ROI
Buffalo Bills: Keys to the Game vs. the Detroit Lions
The Bills are winless (0-1) when making less than 7 explosive plays this season — tied for worst in NFL; League Avg: .387.
The Bills are 6-2 (.750) when making 5 or more explosive passes in a game this season — tied for 6th-best in NFL; League Avg: .537.
The Bills are 4-1 (.800) when not losing a fumble this season — tied for 6th-best in NFL; League Avg: .558.
The Bills are 2-3 (.400) when the opposing team rushes more than 30 times since the 2021 season — 3rd-best in NFL; League Avg: .210.
Detroit Lions: Keys to the Game vs. the Buffalo Bills
The Lions are 3-3-1 (.429) when forcing 2 or more turnovers since the 2021 season — worst in NFL; League Avg: .730.