Our computer prediction projects a lopsided win (28-14) for the Buffalo Bills (2-0) over the Jacksonville Jaguars (0-2) on Monday, Sept. 23 at Highmark Stadium (kickoff at 7:30 p.m. ET).
Bills vs. Jaguars predictions
- Pick ATS: Bills (-5.5)
- Pick OU: Under (45.5)
- Prediction:
Bills 28 – Jaguars 14
Bills vs. Jaguars odds and lines
National Football League odds courtesy of BetMGM. Odds updated Sunday at 7:37 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: Bills (-5.5)
- Moneyline: Bills (-250), Jaguars (+200)
- Total: 45.5 points
Bills betting stats
- Buffalo hasn won once against the spread this season.
- The Bills have no wins ATS (0-1) as a 5.5-point favorite or greater this year.
- Buffalo has had one game (of two) hit the over this year.
Jaguars betting stats
- Jacksonville has posted one win against the spread this season.
- None of Jacksonville’s two games has hit the over in 2024.
- The Jaguars lost the only game they’ve played as the underdog this season.
Bills vs. Jaguars game info
- Game day: Monday, September 23, 2024
- Game time: 7:30 p.m. ET
- TV channel: ESPN
- Location: Orchard Park, New York
- Stadium: Highmark Stadium
- TV channel: ESPN
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