Bills vs. Chiefs Picks, Predictions NFL Week 6: Buffalo Avenges Playoff Loss
Bills vs. Chiefs Picks, Predictions NFL Week 6: Buffalo Avenges Playoff Loss

The most anticipated game of the year in the NFL kicks off Sunday when the Buffalo Bills visit the Kansas City Chiefs after last year's epic playoff game. Here are our Bills-Chiefs picks.

Kansas City has knocked Buffalo out of the playoffs in each of the past two seasons, including January's memorable AFC divisional meeting when the Chiefs edged the Bills 42-36 in OT. With both teams off to 4-1 starts to the 2022 campaign, Sunday's collision at Arrowhead could end up determining which team hosts the other in this year's postse ason.

Will Buffalo exact revenge for last year's playoff loss, or can K.C. hold serve on its home field?

Let's break it down in our Bills-Chiefs picks and predictions for NFL Week 6 (odds via Caesars Sportsbook, DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).

Bills vs. Chiefs Game Info

  
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