Bills vs. Chargers line, odds, start time: Spread pick, best bets for NFL Week 16 game from proven model

The Buffalo Bills continue their push to return to the playoffs when they face the Los Angeles Chargers in a Week 16 game on Saturday at SoFi Stadium in Inglewood, Calif. After starting the season 5-5, the Bills (8-6) have won three of four, including their last two. Meanwhile the Chargers (5-9) have been one of the most disappointing teams in the NFL this season and will be playing their first game after the firing of coach Brandon Staley.

Kickoff is scheduled for 8 p.m. ET. Buffalo is a 12-point favorite in the latest Bills vs. Chargers odds while the over/under for total points scored is 44. Before you make any Chargers vs. Bills picks or NFL predictions, you need to see what the SportsLine Projection Model has to say.
  
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