OddsJam's MLB experts take you through the betting odds, picks and predictions for this MLB matchup between the Houston Astros vs. the Cleveland Guardians on August 6, 2022 in Cleveland.
Astros vs Guardians Betting Odds
The Houston Astros visit the Cleveland Guardians for this MLB matchup on August 6, 2022. First pitch for Saturday's game is 6:10 p.m. ET / 3:10 p.m. PT in Cleveland.
The Houston Astros are favored at -164 vs. the Cleveland Guardians. The Cleveland Guardians are +138 underdogs on the moneyline in this matchup and are +1.5 on the Run Line at -118.