The Notre Dame Fighting Irish (4-3) and Syracuse Orange (6-1) meet Saturday at JMA Wireless Dome in Syracuse, N.Y. Kickoff is scheduled for noon ET (ABC). Below, we look at Notre Dame vs. Syracuse odds from Tipico Sportsbook; check back for all our college football picks and predictions.
The Fighting Irish had little trouble with UNLV at home, posting a 44-21 win as the Over (45.5) cashed. Notre Dame (-25.5) failed to cover for the 2nd straight game, and 4th time in the last 6 games.
The Orange suffered their 1st loss of the season, falling 27-21 at Clemson in a heartbreaker. Syracuse led 21-10 heading to the final quarter before it was outscored 17-0 in the final 15 minutes.
Syracuse is No. 16 in the AFCA Coaches Poll powered by USA TODAY Sports.