The Buffalo Bills (4-1) and Kansas City Chiefs (4-1) face off in a much-anticipated Week 6 matchup Sunday at GEHA Field at Arrowhead Stadium. Kickoff is at 4:25 p.m. ET (CBS). Below, we analyze Tipico Sportsbook’s lines around the Bills vs. Chiefs odds, and make our expert NFL picks and predictions.
This matchup between 2 AFC juggernauts is a rematch of one of the best postseason matchups in recent memory. The Chiefs beat the Bills in the divisional round last season, 42-36, winning the game in overtime after QB Patrick Mahomes only needed 13 seconds to lead the Chiefs down the field to tie things up with a field goal in the 4th quarter.
The Chiefs have beaten the Bills in 3 of their last 4 matchups, with the lone loss coming during the 2021 regular season. Kansas City is 3-1 ATS against the Bills during that span, and the Over is 3-1 as well.
The Chiefs and Bills are the top teams in the AFC — no other team in the conference has 4 or more wins. They boast the league’s 2 best offenses in points per game, and the Bills boast the league’s best defense in points allowed. Both squads also suffered their only losses this season in Week 3: Kansas City lost to the Indianapolis Colts while the Bills were beaten by the Miami Dolphins.