With so much parity in the NFL, the phrase “Any Given Sunday” applies on the gridiron with upsets every week. When betting on the NFL, this is always something to consider.
Below are the biggest underdogs of the week.
NFL Betting Lines Week 6: NFL Underdogs in Week 6
| Rank | Matchup | Favorite | Underdog |
| 1 | Carolina Panthers vs. Los Angeles Rams | Rams (-10.5) | Panthers (+10.5) |
| 2 | Tampa Bay Buccaneers vs. Pittsburgh Steelers | Buccaneers (-8.5) | Steelers (+8.5) |
| 3 | New York Jets vs. Green Bay Packers | Packers (-7.5) | Jets (+7.5) |
| 4 | Dallas Cowboys vs. Philadelphia Eagles | Eagles (-6) | Cowboys (+6) |
| 5. (Tie) | Baltimore Ravens vs. New York Giants | Ravens (-5.5) | Giants (+5.5) |
| 5. (Tie) | San Francisco 49ers vs. Atlanta Falcons | 49ers (-5.5) | Falcons (+5.5) |
| 5. (Tie) | Denver Broncos vs. Los Angeles Chargers | Chargers (-5.5) | Broncos (+5.5) |
| 8 | Minnesota Vikings vs. Miami Dolphins | Vikings (-3.5) | Dolphins (+3.5) |
| 9. (Tie) | New England Patriots vs. Cleveland Browns | Browns (-3) | Patriots (+3) |
| 9. (Tie) | Buffalo Bills vs. Kansas City Chiefs | Bills (-3) | Chiefs (+3) |
| 11. (Tie) | Jacksonville Jaguars vs. Indianapolis Colts | Colts (-2.5) | Jaguars (+2.5) |
| 11. (Tie) | Arizona Cardinals vs. Seattle Seahawks | Cardinals (-2.5) | Seahawks (+2.5) |
| 13 | Cincinnati Bengals vs. New Orleans Saints | Bengals (-2) | Saints (+2) |
| 14 | Washington Commanders vs. Chicago Bears | Bears (-1) | Commanders (+1) |
Football Odds at BetMGM
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