It would be hard to argue the 49ers' 2021 season was anything but a successful one, despite it ending on the doorstep of the Super Bowl. Team brass seems to believe that quarterback Jimmy Garoppolo took the 49ers as far as he could, so the Trey Lance era is now underway in San Francisco.
How will the switch at QB impact the 49ers as they look to take a loaded roster to the promised land in a crowded and competitive NFC West?
Below, we preview the 2022 NFL season for the 49ers with a look at their futures odds and make our top picks (odds via DraftKings Sportsbook and FanDuel Sportsbook).
San Francisco 49ers 2022 Futures Odds
San Francisco 49ers 2022 Picks
- 49ers to win NFC West (+200 via FanDuel)
- Over 9.5 wins (-145 via DraftKings)
- To win the Super Bowl (+1600 via DraftKings)
- Deebo Samuel Offensive Player of the Year (+1600 via FanDuel)
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