Below you’ll find my projected spreads for each game along with one of my best bets of the week: 49ers vs. Panthers. You can find all of my best bets of the week here.
Here are my personal spread projections for each Week 5 game, ordered according to when each game kicks off. The consensus lines are pulled from our BettingPros odds page on Wednesday and are presented – along with my projected lines and edges – from the perspective of the home team. (For the London game, the Packers are technically the home team.)
| Home Team | Road Team | Consensus Line | Freedman Line | Projected Edge |
| DEN | IND | -3.5 | -3.5 | 0 |
| GB | NYG | -8 | -7.75 | 0.25 |
| BUF | PIT | -14 | -13.75 | 0.25 |
| CLE | LAC | 2.5 | 2.25 | -0.25 |
| MIN | CHI | -7 | -7.75 | -0.75 |
| WAS | TEN | 2.5 | 0.25 | -2.25 |
| JAX | HOU | -7 | -6.25 | 0.75 |
| NO | SEA | -5.5 | -4.5 | 1 |
| TB | ATL | -9 | -9.5 | -0.5 |
| NYJ | MIA | 3 | 3 | 0 |
| NE | DET | -3 | -1 | 2 |
| CAR | SF | 6.5 | 4.5 | -2 |
| ARI | PHI | 5.5 | 2.75 | -2.75 |
| LAR | DAL | -5.5 | -6 | -0.5 |
| BAL | CIN | -3 | -2.25 | 0.75 |
| KC | LV | -7 | -9 | -2 |
- Kickoff: Sunday, Oct. 9, 2022, 4:05 pm ET
- Location: Bank of America Stadium
- TV: CBS
49ers at Panthers: Consensus'Lines
- Spread: 49ers -6.5
- Over/Under: 39
- Moneyline: 49ers -275, Panthers +235
49ers at Panthers: Betting Percentages
- Spread: 49ers – 75% bets, 76% money
- Over/Under: Under – 50% bets, 71% money
- Moneyline: Panthers – 18% bets, 38% money
49ers at Panthers: Injuries
49ers: Week 5 Injury Report
| Player | Position | Injury | Wed |
| Trent Williams | OT | Ankle | DNP |
| Colton McKivitz | OT | Knee | DNP |
| Tyrion Davis-Price | RB | Ankle | DNP |
| Tyler Kroft | TE | Knee | DNP |
| Arik Armstead | DT | Foot, Ankle | DNP |
| Javon Kinlaw | DT | Knee | DNP |
| Tarvarius Moore | DB | Hamstring | DNP |
| Nick Bosa | DE | Rest | DNP |
| Ross Dwelley | TE | Rib | LP |
| Jauan Jennings | WR | Ankle | LP |
49ers: IR, PUP & Out
| Player | Pos | Status |
| Azeez Al-Shaair | LB | IR |
| Maurice Hurst | DL | IR |
| Trey Lance | QB | IR |
| Jordan Matthews | TE | IR |
| Elijah Mitchell | RB | IR |
| Curtis Robinson | LB | IR |
| Jimmie Ward | DB | IR |
| Jordan Willis | DL | IR |
| Kalia Davis | DL | NFI |
| Jason Verrett | CB | PUP |
49ers Injury News
Panthers: Week 5 Injury Report
| Player | Position | Injury | Wed |
| Christian McCaffrey | RB | Rest | DNP |
| Laviska Shenault Jr. | WR | Hamstring | DNP |
| Stantley Thomas-Oliver | CB | Thigh | DNP |
| Xavier Woods | S | Hamstring | DNP |
| Marquis Haynes | DE | Knee | LP |
| Frankie Luvu | OLB | Shoulder | LP |
| Shaq Thompson | OLB | Knee | LP |
| Stephen Sullivan | TE | Back | FP |
Panthers: IR, PUP & Out
| Player | Pos | Status |
| Jeremy Chinn | S | IR |
| Matt Corral | QB | IR |
| Sam Darnold | QB | IR |
| Zane Gonzalez | K | IR |
| Andre Roberts | WR | IR |
| Bravvion Roy | DT | IR |
| Julian Stanford | LB | IR |