The Carolina Panthers play at home for the fourth time already this season as they host the San Francisco 49ers in Week 5. Homefield hasn't been much of an advantage though, as the Panthers are 1-2 in Charlotte.
Carolina is 1-3 straight up and against the spread and are 1-2 ATS at home. The 49ers are 0-2 on the road and 2-2 overall. San Francisco is 2-2 ATS the spread and 0-2 ATS on the road.
The Panthers lost to the Arizona Cardinals, 26-16, at home as one-point favorites in Week 4. Carolina led 10-3 at the break but allowed 24 unanswered points in the second half before Christian McCaffery caught a 13-yard TD pass from Baker Mayfield with 4:47 left. That was the Panther's lone offensive touchdown in the game. Frankie Luvu had the other, scoring the first points of the game with a 33-yard interception return early in the second quarter.