We’re here to get you ready for Week 5. You can check out all of our early Week 5 NFL content below, including our early picks and predictions for the week ahead. And here’s a closer look at the NFL Week 5 matchup: Steelers vs. Bills.
- Matthew Freedman's NFL Week 5 Early Bets and Trends
- NFL Week 5 Early Lines vs. Line Movement Predictions
- Video: NFL Week 5 Early Odds, Picks & Predictions
Prop Bet Analyzer: View top-rated props and historical prop performance by player >>
The largest spread of the week belongs to the Steelers vs. the Bills. Kenny Pickett will likely make his first start in the NFL after scoring two touchdowns and throwing three interceptions in relief against the Jets. Meanwhile, the Bills will look for their first lopsided victory since Week 2 after two contentious games against the Dolphins and Ravens.